Oxycodone/APAP Addiction, Abuse, and Misuse - Oxycodone and acetaminophen tablets expose patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess. Respiratory depression is a hazard with the use of oxycodone, one of the active ingredients in Oxycodone and Acetaminophen Tablets, as with all opioid agonists. Oxycodone and acetaminophen tablets are used to manage pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate, and when other pain treatments such as non-opioid pain medicines do not treat your pain well enough, or you cannot tolerate them. Oxycodone and Acetaminophen Tablets are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Oxycodone acts on the central nervous system (CNS) to relieve pain. Oxycodone extended-release capsules or tablets should not be used if you need pain medicine for just a short time, such as when recovering from surgery. Find patient medical information for Oxycodone/Acetaminophen (Percocet, Tylox, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user. Oxycodone is a semisynthetic pure opioid agonist whose principal therapeutic action is analgesia. Other pharmacological effects of oxycodone include anxiolysis, euphoria and feelings of relaxation. This guide compares prescription opioids (oxycodone and hydrocodone) against over-the-counter analgesics (acetaminophen, ibuprofen, and naproxen) across various pain conditions. Oxycodone and acetaminophen combination can cause serious unwanted effects or fatal overdose if taken by children, pets, or adults who are not used to strong opioid pain medicines. This combination medication is used to help relieve moderate to severe pain. It contains an opioid pain reliever (oxycodone) and a non-opioid pain reliever (acetaminophen). Oxycodone works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a fever.